David J. Peck’s Or Perish in the Attempt ingeniously combines the remarkable adventures of Lewis and Clark with an examination of the health problems their expedition faced. Formidable problems indeed, but the author patiently, expertly—and humorously—guides us through the medical travails of the famous journey, juxtaposing treatment then against remedy now. The result is a fascinating book that sheds new light not only on Lewis and Clark and the men and one remarkable woman (and her infant) who accompanied them along an eight-thousand-mile wilderness path but also on the practice of medicine in their time and place.